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MCL

Medicinal Chemistry Lab (MCL)

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Faculty
David Julián Sanabria-Ríos, Ph.D.

Contact information

Faculty of Science and Technology -Department of Natural Sciences 4th Floor -John Will Harris Building
Inter American University of Puerto Rico - Metropolitan Campus PO Box 191293 San Juan, PR 00919

Email: dsanabria@intermetro.edu
Office: 450
Labs : 403 and 435-B
Office Phone: (787) 250-1912, Ext. 2465
Lab phone: (787) 250-1912, Ext 2313 and 2332

Rank/Discipline
Associate Professor and Researcher/ Organic Chemist, Medicinal Chemist, Natural Product Researcher, and Chemical Education Researcher (CER)

Courses that i teach
Organic Chemistry I (CHEM 2221) and Organic Chemistry II (CHEM 2222)

Education & Specialty Certification
Post Doctorate Experience, 2009, Miami University, Oxford, Ohio PhD, 2007, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico

 

PI: David Julián Sanabria-Ríos, Ph.D.

Research Description

My research lab is focused at synthesizing novel small molecules derived from natural products. Specifically, we are interested in synthesizing fatty acids and curcuminoids derivatives because these compounds have shown interesting antimicrobial and anticancer properties. In order to investigate the activity and potency of these compounds, I am employing diverse and modern cellular and biochemical assays, with a particular emphasis in the inhibition of microbial DNA topoisomerases and ATPases. DNA topoisomerases are enzymes that are related to the replication of both microbial and cancer cells, while ATPase are involved with microbial conjugation of resistance genes. Compounds that can inhibit both DNA topoisomerases and ATPases are good candidates for the design of novel antibacterial and anticancer drugs.